In this prospective study, the investigators will evaluate and compare the usefulness of functional and volumetric informations obtained by 18F-FDG PET and MRI before and after the palliative chemotherapy with the aim of predicting tumor response and prognosis in patients with advanced Non-small Cell Lung Cancer (NSCLC).
Study cohort will undergo PET/CT and MRI scans prior to chemotherapy and after the first chemotherapy cycle. MRI scans include DCE-MRI and DWI. The following parameters will be calculated using these values: 1. Metabolic parameters on FDG-PET A. SUV change ratio (SCR) = SUVpost/SUVpre B. MTV change ratio (VCR) = MTVpost/pre C. TLG change ratio = SCR X VCR 2. Perfusion parameters on DCE-MRI A. Kep B. K-trans C. ve 3. Diffusion parameters on DWI A. Mean ADC B. fDM
Study Type
OBSERVATIONAL
Enrollment
35
Samsung Medical Center
Seoul, South Korea
DWI, DCE-MRI, and FDG PET as early predictor for response and prognosis
The primary endpoint of this study is the prediction of one-year overall survival by monitoring the metabolic and functional responses of the tumor following one cycle of chemotherapy.
Time frame: one year
Correlation among DWI, DCE-MRI, and FDG PET and relationship with prognosis
Correlation among metabolic response, functional response on MRI, and standard anatomic response using the RECIST criteria
Time frame: one year
Correlation among DWI, DCE-MRI, and FDG PET and relationship with prognosis
(i) the correlation among metabolic response, functional response on MRI, and standard anatomic response using the RECIST criteria (ii) the correlation between functional response (metabolic and MR parameters) and progression-free survival (iii) comparison between the predictive values of FDG-PET and MRI for one-year overall survival.
Time frame: one year
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