L-Arginine, Vascular Response and Mechanisms

Brigham and Women's Hospital25 enrolled

Overview

The purpose of the study is to employ the supplement L-arginine to test the hypothesis that activation of blood flow to the brain during cognitive tasks is regulated by nitric oxide in older subjects with diabetes mellitus and/or hypertension (high blood pressure).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Hypertension Diabetes

Interventions

L-ArginineDIETARY_SUPPLEMENT

Dietary Supplement

Placebo SupplementDIETARY_SUPPLEMENT

Dietary Supplement

Eligibility

Sex: ALLMin age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * diabetes and/or hypertension Exclusion Criteria: * alzheimers disease, dementia, stroke, active herpes, recent angina or heart attack

Locations (1)

Brigham and Women's Hospital

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

Functional transcranial doppler measures

Time frame: 6 weeks

Secondary Outcomes

Flow Mediated Dilation (FMD)

Time frame: 6 weeks

Finger Blood Flow - Plethysmography (PAT)

Time frame: 6 weeks

Data from ClinicalTrials.gov

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