Continuous Infusion of Palonosetron for Preventing of Postoperative Nausea and Vomiting

Incheon St.Mary's Hospital132 enrolled

Overview

The purpose of this study is to determine whether continuous infusion of palonosetron after its prophylactic single injection can further reduce the incidence of postoperative nausea and vomiting in patients undergoing gynecological laparoscopic surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

132

Conditions

Postoperative Nausea and Vomiting

Interventions

continuous infusion of palonosetron added to prophylactic single injection of palonosetronDRUG

continuous infusion of palonosetron 0.00075 mg/hour after single injection of palonosetron 0.075mg

continuous infusion of normal saline added to prophylactic single injection of palonosetronDRUG

continuous infusion of normal saline after single injection of palonosetron 0.075mg

Eligibility

Sex: FEMALEMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA Physical Status 1 or 2 * Elective gynaecological laparoscopic surgery of ≥ 1h duration Exclusion Criteria: * Anti-emetics, steroids, or psychoactive medications within 24 h of study initiation * Vomiting or retching in the 24 h preceding surgery * Cancer chemotherapy within 4 weeks or emetogenic radiotherapy within 8 weeks before study entry * Ongoing vomiting from gastrointestinal disease

Locations (1)

Incheon St Mary's hospital

Incheon, South Korea

RECRUITING

Outcomes

Primary Outcomes

incidence of postoperative nausea and vomiting

Time frame: 24 hours after surgery

Secondary Outcomes

severity of nausea

Time frame: for 24 hours after sugery

Central Contacts

Soo Kyoung Park

CONTACT

82-32-280-5410 hardmong@korea.com

Data from ClinicalTrials.gov

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