ALX-0171 Phase I Study, Evaluating Single Ascending Dose and Multiple Dose in Healthy Male Volunteers

Inclusion Criteria: * Non-smoking healthy male volunteers, aged 18-55 years * Good health condition, as determined by medical history, physical examination and clinical laboratory testing * Forced expiratory volume in 1 second (FEV1) ≥ 90% of predicted value * Diffusing capacity of the lung for CO (DLCO) ≥ 85% of predicted value * Normal chest X-Ray (anteroposterior and lateral view) * Minimum weight of 70.0 kg, minimum height of 1m70, body mass index between 18.0 and 30.0 kg/m² Exclusion Criteria: * Current smokers, or ex-smokers abstinent from tobacco for less than one year * History or presence of atopy or pulmonary non-specific hyperreactivity * Positive bronchial challenge test * Symptomatic viral infection, or suspicion thereof (including rhinitis) in last 14 days prior to dosing * Signs of active pulmonary infection or other inflammatory conditions, even in the absence of febrile episodes, in the last 14 days prior to dosing