Efficacy and Safety Study to Delay Renal Failure in Children With Alport Syndrome

Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH66 enrolled

Overview

This is a phase III, multi-centre, randomised, placebo-controlled, patient and investigator-blind study in paediatric patients with early stages of Alport syndrome to assess the safety and efficacy of the ACEi ramipril in slowing disease progression. Alport syndrome stages that describe the extent of renal damage and loss of function are defined as: * 0 Microhaematuria without microalbuminuria (usually at birth) * I Microalbuminuria (30-300 mg albumin/gCrea) * II Proteinuria \>300 mg albumin/gCrea * III \> 25% decline of normal renal function (creatinine clearance) * IV End stage renal failure (ESRF) Eligible patients with Alport stages 0 and I will be randomly assigned at a 2:1 ratio to receive once daily ramipril or placebo. In addition, Alport stage II patients may be treated open Label. Eligible patients who, or whose parents/legal guardian refuse randomisation after eligibility is confirmed, and patients who have been treated with ramipril prior to the study, may be treated open-label with ramipril as per protocol. The total number of patients will not exceed 120, with the number of randomised patients not exceeding 60, and the number of patients treated open label from Day 1 of the study aimed to be approximately 60. Randomised patients whose disease progresses to the next disease level during the 3 year treatment period will be unblinded, and open label ramipril treatment will be initiated and continued, respectively, depending on prior treatment randomisation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Renal Insufficiency, Chronic

Interventions

RamiprilDRUG

Ramipril (Delix) tablets containing 2.5 mg ramipril, oral application with 1 to 6 mg per body surface area ramipril once daily for 3 years.

placebo to ramiprilDRUG

Oral application of placebo to ramipril, once daily with 1 to 6 mg per body surface area for 3 years or until disease progression.

RamiprilDRUG

Oral treatment with 1 to 6 mg per body surface area ramipril once daily for 3 years as per protocol.

Eligibility

Sex: ALLMin age: 24 MonthsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Definitive diagnosis of Alport syndrome: Kidney biopsy (patient or affected relative/s), and/or mutation analysis (hemizygous X-chromosomal or homozygous autosomal-recessive) and assessment of criteria for clinical diagnosis (haematuria, positive family history regarding kidney diseases, ocular changes, labyrinthine hearing loss) * Alport syndrome levels 0, I or II at screening (microhaematuria without microalbuminuria or microalbuminuria \[30-300 mg albumin/gCrea\]) or proteinuria \>300 mg albumin/gCrea with GFR\>80ml/min). Patients with Alport stage II are not subject to randomization but are treated opel label. * Aged between ≥24 months and \<18 years at screening * Assent from patient and informed consent from parents/legal guardian Exclusion Criteria: * Uncertain diagnosis or variants of Alport syndrome such as a heterozygous carrier * Alport syndrome levels III, or IV (albuminuria \>300 mg/g Crea, creatinine clearance \<60 mL/min, or end stage renal failure \[ESRF\]) * Known allergies or intolerances to ramipril or related compounds * Known contraindication for ACEi-therapy * Additional chronic renal, pulmonary or cardiac diseases * Pregnancy and lactation

Outcomes

Primary Outcomes

Time to next disease level

Time to progression of Alport Syndrome to the next disease level within 3 years under ramipril treatment compared to placebo, for all randomised patients.

Time frame: within 3 years

Incidence of Adverse Drug Events before progression

Incidence of adverse drug events (ADEs, e.g., angioedema, acute renal failure, hyperkalaemia) under ramipril treatment before disease progression compared to placebo before disease progression, for all randomised patients.

Time frame: within 3 years

Secondary Outcomes

Albuminuria after three years

Albuminuria after 3 years corrected for baseline albuminuria for patients randomised to receive ramipril compared to placebo.

Time frame: after 3 years

Adverse Drug Events over three years

Incidence of ADEs (e.g., angioedema, acute renal failure, hyperkalaemia) during 3 years of treatment for patients randomised to receive ramipril compared to placebo.