Clinical Outcomes of Topical Ganciclovir Treatment in Cytomegalovirus Anterior Uveitis

National Taiwan University Hospital60 enrolled

Overview

The purpose of this study was to evaluate long term efficacy and safety of topical ganciclovir treatment in Cytomegalovirus (CMV) anterior uveitis.

The investigators will enroll 60 patients with positive results of the CMV PCR (polymerase chain reaction) from aqueous humor tapping from January 2006 to June 2011. All the patients (40 men, 20 women) were immunocompetent and diagnosed as symptomatic CMV infection. Their medical records will be reviewed, including demographic data as well as their ophthalmic and medical histories. The purpose of this study was to evaluate long term efficacy and safety of topical ganciclovir treatment in CMV anterior uveitis.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Anterior Uveitis

Eligibility

Sex: ALLMin age: 40 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with positive results of the CMV PCR (polymerase chain reaction) from aqueous humor tapping. All the patients were immunocompetent and diagnosed as symptomatic CMV infection. Exclusion Criteria: * Patients without positive results of the CMV PCR * Immunocompromised patients with positive results of the CMV PCR

Locations (1)

National Taiwan University Hospital

Taipei, Taiwan

RECRUITING

Outcomes

Primary Outcomes

Anterior chamber inflammation

anterior chamber cell grading based on slit lamp microscopy

Time frame: 4 weeks after starting treatment

Secondary Outcomes

probability of relapse-free

Kaplan-Meier curve of relapse-free probability

Time frame: 2 years after treatment

Central Contacts

I-Jong Wang, M.D. PhD

CONTACT

886-23123456 ijong@ntu.edu.tw

Data from ClinicalTrials.gov

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