A Phase I-II Open Label Non-Randomized Study Using TL32711 for Patients With Acute Myelogenous Leukemia, Myelodysplastic Syndrome and Acute Lymphoblastic Leukemia

Inclusion criteria * Subjects with a diagnosis of non-M3 AML, Relapsed or refractory ALL or Intermediate Risk 2 or High Risk disease MDS as follows: * Subjects with a diagnosis of non-M3 AML which meets one of the following criteria: 1. Ages 60 or older: Relapsed or refractory after at least one prior therapy for AML 2. Ages 60 or older: Newly diagnosed in a patient with a preceding history of myelodysplastic syndrome which has been treated with azacitidine or decitabine and who are not appropriate candidates for aggressive therapy including induction followed by allogeneic stem cell transplantation 3. Ages 18-59: Relapsed or refractory disease after failing three prior lines of therapy * Subjects with a diagnosis of relapsed or refractory ALL: must have failed three prior lines of therapy and be 18 years of age or older. * Subjects with a diagnosis of Intermediate Risk 2 or High Risk disease (as defined by IPSS score): 1. Must have failed to respond/intolerant to, or progressed after a hypomethylating agent, and must not be candidates for allogeneic stem cell transplantation 2. Life expectancy of at least 4 weeks 3. Must have recovered from toxic effects of prior chemotherapy 4. Patients must be able to sign consent and be willing and able to comply with scheduled visits, treatment plan and laboratory testing. Exclusion criteria * Cytotoxic chemotherapy (including azacitidine or decitabine) within the past 28 days other than hydroxyurea * Active participation in any other investigational treatment study for AML. * ECOG performance status greater than 2 * Uncontrolled intercurrent illness including, but not limited to: uncontrolled ongoing infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. * QT interval corrected for heart rate (QTcB) greater than 480 msec (including subjects on medication). Subjects with a ventricular pacemaker for whom QT interval is not measurable may be eligible for enrollment after consultation with the drug manufacturer and study Medical Monitor, and written documentation of this approval. * Female subjects who are pregnant or breastfeeding