mFOLFIRI Combine With Nimotuzumab Second Line Chemotherapy for Squamous-cell Carcinoma of the Esophagus

Inclusion Criteria: * Histologically confirmed esophageal squamous carcinoma,failed to 1st line treatment of paclitaxel/cisplatin * Age 18 to 75 years old * Measurable disease according to the RECIST criteria(diameter of the lesion should be more than 10mm by spiral CT or MRI, more than 20mm by common CT, the date of image should be less than 15 days before enrollment) * Life expectancy of ≥3 month * Karnofsky performance status ≥80 * WBC\>3,500/mm3, absolute neutrophil count ≥2000/mm3, platelet\>100,000/mm3, Hb\>9g/dl，Bilirubin level \< 1.0 times ULN，Serum creatinine \<1.0 times ULN，ALT and AST\<2.5 times ULN ，AKP \< 2.5 times ULN ，(≤5 times ULN in patients with liver metastases)(within 7 days before enrollment) * No sever complication, such as active gastrointestinal bleeding, perforation, jaundice, obstruction, non-cancerous fever\>38℃； * Normal ECG/cardiac function * Good compliance * Having signed informed consent Exclusion Criteria: * More than 1 Previous systemic therapy for metastatic esophageal squamous carcinoma * Known hypersensitivity to study drugs * Tumor with length≥10cm, liver metastasis covers more than 50% of liver,or lung metastasis covers more than 25% of lung * No measurable lesions, eg. pleural fluid and ascites * Only with Other previous malignancy within 5 year, except non-melanoma skin cancer * Heart failure or other sever organ dysfunction, eg. coronary artery disease, myocardial infarction within the last 6 months only Brain or bone metastasis * Chronic diarrhea * Mentally abnormal or disable cognition,including CNS metastasis * Pregnancy or lactation period