Prediction of Cognitive Properties of New Drug Candidates for Neurodegenerative Diseases in Early Clinical Development

Inclusion Criteria: * 18-30 year old male non-smoker subjects * Subject without cognitive impairment or cognitive complaint (Moca\>26, Mac Nair scale\<15) * Subject without history of brain disease (severe brain trauma, stroke, cerebral tumor,…) * Subject without major medical or surgical history * Subject without current chronic disease * Subject without current cerebral disease * Subject without vascular or metabolic risk factor * Subject without history or current mental disease or addiction (MINI) * Subject without lesion on MRI * Subject without abnormal electrical activities on EEG * Subject without use of chronic treatment or psychotropic drugs or substances * French speaker subject and able to understand the test instructions Exclusion Criteria: * Subject with age \< 18 years or \> 30 years * Subject with dementia or cognitive decline identified by Moca \< 26 * Subject with history of brain disease (brain trauma, stroke, cerebral tumor,…) * Subject with major medical or surgical history * Subject with current chronic disease * Subject with current cerebral disease * Subject with vascular or metabolic risk factor * Subject with history or current mental disease or addiction * Subject with family history of young-onset dementia * Subject with family history of chronic or severe neurological or mental disease (first degree relatives) * Subject with lesion on MRI * Subject with abnormal electrical activities on EEG * Subject receiving a chronic treatment * Subject using chronically or acutely psychotropic drugs or substances * Subject with claustrophobia or contra-indication to MRI * Subject unable to understand the test instructions