Efficacy of 0.05% Cyclosporin Eye Drop in Stevens Johnson Syndrome Patient With Chronic Dry Eye

Inclusion Criteria: * Males or females, of legal age of consent * Patient with Stevens-Johnson syndrome in chronic stage or has symptoms more than 3 months and has dry eye symptoms * Dry eye symptoms are defined as 1. has dry eye symptom everyday for more than 3 months 2. has foreign body sensation frequently 3. use tear substitutes more than 3 times per day * Tear test shaw abnormalities at least 1 of 2 of following: 1. Schirmer test without anesthesia is not more than 5 millimeters in 5 minutes 2. Fluorescein clearance test at first 10 minutes is not more than 3 millimeters and has at least 1 of 3 of the following: 2.1.Rose Bengal score is not less than 4 2.2.Fluorescein stain at cornea 2.3.Impression cytology is consistent to dry eye * Patent punctum Exclusion Criteria: * Age \< 18 years old * Patients with Steven Johnson syndrome without dry eye * Patients used oral cyclosporine or anticholinergic drug within past 2 months * Patients with HIV or immunocompromise status * Patients with active ocular infections and patients with a history of herpes keratitis * Patients with known or suspected hypersensitivity to any of the ingredients in the formula (cyclosporine, glycerin, castor oil, polysorbate 80, carbomer 1342) * Female patients are pregnant or nursing