Air pollution is linked to respiratory and cardiovascular disease. Wood smoke is a common air in many parts of the world and previous studies indicate that wood smoke induce oxidative stress in the respiratory tract. It is not determined how different types of biomass combustion affect human health. In this study the investigators plan to investigate how inhalation of wood smoke and pellets smoke affect respiratory and cardiovascular health.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
20
24 hours after exposure, a bronchoscopy will be performed to allow analysis of cells and inflammatory markers in bronchial wash, bronchioalveolar lavage and lung biopsies.
Umeå University
Umeå, Sweden
Respiratory inflammation
Bronchoscopy will be performed, and samples collected by bronchoalveolar lavage and bronchial biopsy. Samples will be analysed for cell counts, histology and inflammatory markers.
Time frame: 24 hours after exposure to air or woodsmoke
Central arterial stiffness
Central arterial stiffness will be measured at baseline and for the 1 hour following the exposure using the SphygmoCor and Vicorder devices
Time frame: Baseline and for 1 hour after exposure
Heart rate variability
Continuous electrocardiograms will be recorded using a holter monitor to determine heart rate variability
Time frame: 24 hours after the exposure
Systemic inflammation
Blood samples will be taken at intervals following the exposure to woodsmoke to measure circulating inflammatory markers
Time frame: 24 hours after the exposure
Lung function
Lung function will be assessed using spirometry before and after each exposure
Time frame: Baseline and 24hrs after exposure
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