Phase I Study to Investigate the Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of CJ-12406 in Healthy Male Subjects

Inclusion Criteria: 1. Male volunteers in the age between 20 and 45 years old 2. Subjects with no history of any significant chronic disease 3. The weight range is not exceed ±20% of ideal weight. Ideal weight = \[height -100\]\*0.9 4. Judged to be in good health on the basis of their vital sign, ECG, physical exam and routine laboratory data 5. Available for the entire study period 6. Willing to adhere to protocol requirements and sign a informed consent form 7. Multiple escalation study; H. pylori positive, as determined by the urea breath test Exclusion Criteria: 1. History of clinically significant allergies including drug allergies 2. History of clinically significant hepatic, renal, gastrointestinal, pulmonary, ,musculoskeletal, endocrine, psychiatric, hematologic, oncologic, neurologic or cardiovascular disease 3. Symptom of an acute illness within 4 weeks prior to drug administration 4. History of surgery except or gastrointestinal diseases which might significantly change absorption of medicines 5. Treatments or symptoms of symptomatic GERD, gastric ulcer, duodenal ulcer, functional dyspepsia, irritable bowel syndrome within 3 months prior to drug administration 6. Clinical laboratory test values are outside the accepted normal range * AST or ALT \>1.25 times to normal range * Creatinine clearance \<80 mL/min * 12-lead ECG; PR ≥ 210 msec, QRS ≥ 120 msec, QT ≥ 500 msec, QTcF ≥ 450 msec 7. Clinically significant vital signs * Hypotension (SBP ≤ 89 mmHg) * Hypertension (SBP ≥ 141 mmHg or DBP ≥ 91 mmHg) * Tachycardia (≥ 101 beats/min) 8. History of drug and alcohol abuse(alcohol \> 30 g/day) 9. Subjects who have ever smoke within 3 months prior to drug administration 10. Positive urine screen for drugs and cotinine 11. Use of any other medication, including herbal products, within the 2 weeks before dosing 12. Special diet known to interfere with the absorption, distribution, metabolism or excretion of drugs (especially, consumption of grapefruit juice) within 7 days prior to drug administration 13. Donated blood within 60 days prior to dosing 14. Participated in a previous clinical trial within 90 days prior to dosing 15. Subjects considered as unsuitable based on medical judgement by investigators