The purpose of this study is to assess whether estrogen pre-treatment can allow retrieval of 2 additional oocytes in GnRH antagonist protocol.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
472
Pretreatment with 17beta-estradiol (Provames®, Aventis, Paris, France) was administered daily (2 mg twice a day) during the cycle preceding the IVF/ICSI cycle, starting 7 days before the predicted onset of menses and administered up until to the following Thursday after the occurrence of menses.
Service de Medecine de la Reproduction, Hôpital Jean Verdier
Bondy, Île-de-France Region, France
number of retrieved oocytes
Time frame: at the ovarian puncture, 36 hours post HCG administration
pregnancy rate
Time frame: at pregnancy test and at 6 Week US examination
delivery rate
Time frame: 9 months later
number of obtained embryos
Time frame: 2 days after in vitro fertilization
duration of FSH administration
number of days of administration
Time frame: at the end of ovarian stimulation usually after a mean of 12 days of administration
Total FSH dose
daily dose x number of days of administration
Time frame: at the end of ovarian stimulation usually after a mean of 12 days of administration
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