Embryo Selection Using Non-invasive Metabolomic Analysis Versus Morphology

Eugonia125 enrolled

Overview

Metabolomics was recently introduced in human IVF for non-invasive identification of viable embryos with the highest developmental competence. The investigators intended to investigate if embryo assessment using non-invasive metabolomic profiling leads to increased implantation rates compared to routine morphology evaluation alone.

Metabolomics was recently introduced in human IVF for non-invasive identification of viable embryos with the highest developmental competence. The aim of the present study was to determine whether embryo selection using non-invasive metabolomic profiling as an adjunct to morphology leads to increased implantation rates compared to routine morphology evaluation alone.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

NONE

Enrollment

125

Conditions

Embryo Viability

Interventions

non-invasive metabolomic profilingPROCEDURE

non-invasive metabolomic profiling of IVF human embryos

morphological evaluationOTHER

Simple microscopic observation of embryos and evaluation of morphological characteristics

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 49 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * patients with at least 4 fertilized oocytes Exclusion Criteria: * patients with less that 4 fertilized oocytes

Locations (1)

Eugonia ART Unit

Athens, Attica, Greece

Outcomes

Primary Outcomes

Implantation rates

To compare non-invasive metabolomic profiling and the traditional method of morphology assessment for embryo selection in terms of implantation and pregnancy rates in a clinical IVF program.

Time frame: 6 weeks of pregnancy

Data from ClinicalTrials.gov

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