Healthy Normal Volunteers Looking at Exposure and Effects of Multiple Doses of Technosphere® Insulin (TI) Using the Gen2C Inhaler

Inclusion Criteria: * Men and women aged 18 to 55 years who are considered healthy based on screening physical examination, medical history, clinical chemistry, and urinalysis * Good venous access for blood draws * No smoking in the previous 6 months (including cigarettes, cigars, pipes) and negative urine cotinine testing (\< 100 ng/mL) * Body mass index (BMI) \< 32 kg/m2 * FEV1 = 80% of the Third National Health and Nutrition Examination Survey (NHANES III) predicted * FVC = 80% of the Third National Health and Nutrition Examination Survey (NHANES III) predicted * Written informed consent provided Exclusion Criteria: * Blood donation of 500 mL within the previous 56 days * Fasting blood sugar \>130 mg/dL * History of coronary artery disease, peripheral vascular disease, or congestive heart failure * Allergy to study drug, food, or other study material (eg, peanuts, soy products) * Clinically significant active or chronic illness * History of asthma, COPD, or any other clinically relevant chronic lung disease * Respiratory tract infection within 4 weeks before screening * Donation of blood within 3 months before screening * History of drug or alcohol abuse * Positive urine drug screen * Clinically significant screening ECG, physical examination, laboratory test, or vital sign abnormality * Any subject who, in the opinion of the PI or a designee, appears to not be qualified for this study * Exposure to any other investigational drug or device within 30 days before treatment or within 90 days before treatment for drugs known to modify glucose metabolism (except metformin * History of malignancy within the 5 years before screening (other than basal cell carcinoma) * History of human immunodeficiency virus (HIV) infection or hepatitis B or C * Women who are pregnant, lactating, or planning to become pregnant during the clinical study period * Any subject who at Visit 2 has a blood glucose value = 150 mg/dL 2 hours after the meal, should be discussed with the MKC medical monitor and may be removed as potentially having impaired glucose tolerance * Inability, in the opinion of the PI or a designee, to adequately inhale TI Inhalation Powder * Women of childbearing potential (defined as premenopausal and not surgically sterilized or postmenopausal for fewer than 2 years) not practicing adequate birth control. Adequate birth control is defined as using oral, percutaneous, or transdermal contraceptives; condoms and diaphragms (double barrier) with a spermicide; or intrauterine devices. Postmenopausal for the purposes of this clinical study includes experiencing amenorrhea for 2 or more years or being surgically sterile