A Trial of Single Agent Axitinib as Maintenance Therapy for Patients With First Line Metastatic Colorectal Cancer (mCRC)

Inclusion Criteria: * Histologically or cytologically confirmed metastatic adenocarcinoma of the colon or rectum. * Patients must have measurable disease per RECIST Version 1.1. * No previous systemic therapy for metastatic colorectal cancer. Previous radiosensitizing chemotherapy is allowed, if completed at least 4 weeks prior to Cycle 1 Day 1 of study treatment, and previous neoadjuvant and/or adjuvant chemotherapy is allowed, if completed at least 6 months prior to diagnosis of metastatic disease. * Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0 to 1. * Life expectancy \>=12 weeks. * Adequate hematologic, renal and hepatic function * Patients who are on coumadin should have an INR value within the therapeutic range (i.e., 2 to 3 x ULN). Patients who are on stable, chronic doses of coumadin are eligible. * Male patients willing to use adequate contraceptive measures. Female patients who are not of child-bearing potential, and female patients of child-bearing potential who agree to use adequate contraceptive measures, who are not breastfeeding, and who have a negative serum or urine pregnancy test performed within 72 hours prior to start of treatment. * Willingness and ability to comply with the trial and follow-up procedures. * Ability to understand the investigative nature of this trial and give written informed consent. Exclusion Criteria: * History or known presence of central nervous system (CNS) metastases. * Patients who have had a major surgical procedure (not including mediastinoscopy), or significant traumatic injury \<=4 weeks prior to beginning treatment. * Women who are pregnant or lactating. All females of child-bearing potential must have negative serum or urine pregnancy tests within 72 hours prior to study treatment (see Appendix D) * History of hypersensitivity to active or inactive excipients of any component of treatment (5 fluorouracil, bevacizumab, oxaliplatin, or axitinib), or known dipyrimidine dehydrogenase deficiency. * Patients with proteinuria at screening as demonstrated by: * Urine dipstick for proteinuria \>=2+ (patients discovered to have \>=2+ proteinuria on dipstick urinalysis at baseline should undergo a 24-hour urine collection, and must demonstrate \<=1 g of protein/24 hours to be eligible) * Patients with a serious non healing wound, active ulcer, or untreated bone fracture. * Patients with evidence of bleeding diathesis or significant coagulopathy (in the absence of therapeutic anticoagulation). * Patients with history of hematemesis or hemoptysis (defined as having bright red blood of ½ teaspoon or more per episode) \<=1 month prior to study enrollment. * Patients requiring concomitant treatment with potent CYP3A4 or CYP1A2 inducers and CYP3A4 inhibitors. * History of myocardial infarction or unstable angina \<=6 months prior to beginning treatment. * Inadequately controlled hypertension (defined as systolic blood pressure \>150 mmHg and/or diastolic blood pressure \>100 mmHg while on antihypertensive medications). Initiation of antihypertensive agents is permitted provided adequate control is documented at least 1 week prior to Day 1 of study treatment. * New York Heart Association Grade II or greater congestive heart failure. * Serious cardiac arrhythmia requiring medication. Patients with chronic, rate-controlled atrial fibrillation are eligible. * Significant vascular disease (e.g., aortic aneurysm requiring surgical repair, or recent peripheral arterial thrombosis) \<=6 months prior to Day 1 of treatment. * History of stroke or transient ischemic attack \<=6 months prior to beginning treatment. * Any prior history of hypertensive crisis or hypertensive encephalopathy. * History of abdominal fistula or gastrointestinal perforation \<=6 months prior to Day 1 of beginning treatment. * Concurrent severe, intercurrent illness including, but not limited to, ongoing or active infection, or psychiatric illness/social situations that would limit compliance with study requirements. * Any known positive test for human immunodeficiency virus, hepatitis C virus or acute or chronic hepatitis B infection. * Mental condition that would prevent patient comprehension of the nature of, and risk associated with, the study. * Use of any non-approved or investigational agent \<=28 days prior to administration of the first dose of study drug. Patients may not receive any other investigational or anti-cancer treatments while participating in this study. * Past or current history of neoplasm other than the entry diagnosis with the exception of treated non-melanoma skin cancer or carcinoma in situ of the cervix, or other cancers cured by local therapy alone and a disease free survival \>=5 years. * Infection requiring IV antibiotics. * Impairment of gastrointestinal function or gastrointestinal disease that may significantly alter drug absorption (e.g. active inflammatory bowel disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome or significant small bowel resection). * Inability to swallow whole tablets. * Patients with \> Grade 2 peripheral neuropathy.