Mainstream of current treatment of liver cirrhosis is liver transplantation, but there are high cost, risk and immune rejection and other issues. Umbilical cord mesenchyma stem cell with self-and directed differentiation capacity can effectively rescue experimental liver failure and contribute to liver regeneration, which suggests the feasibility of stem cell transplantation therapy. In this study, the safety and efficacy of umbilical cord mesenchyma stem cell transplantation through interventional procedures in patients liver cirrhosis will be evaluated.
This study included three research centers, each center were carried out 25 cases of liver cirrhosis in patients with stem cell transplantation. All the selection and exclusion criteria are same, data summary and analysis will be complete by the epidemiological commissioner.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
75
one time interventional procedures
Yihua An
Beijing, China
RECRUITINGliver volume calculated by MRI
Instrument:universal 1.5 Tesla superconducting MRI instrument. Slice thickness :2mm.
Time frame: 3 days before transplantation, 6 and 12 months after transplantation
liver biopsy
The result of liver biopsy judged by the expert.
Time frame: whinin 7 days before transplantation, 6 and 12 months after transplantation
gastroscopy
Observe and photograph the related varicose veins.
Time frame: whinin 7 days before transplantation, 6 and 12 months after transplantation
blood biochemistry
1. alanine aminotransferase 2. aspartate aminotransferase 3. gamma-glutamyltransferase(GGT) 4. alkaline phosphatase 5. total bilirubin 6. direct bilirubin 7. The total bile acid (TBA) 8. serum cholinesterase (CHE) 9. total cholesterol (TC) 10. albumin 11. the proportion of white balls
Time frame: whinin 7 days before transplantation, 1,3,6 and 12 months after transplantation
blood test
1. platelet count (PLT) 2. mean platelet volume (MPV) 3. platelet distribution width (PDW) 4. platelet hematocrit (PCT) 5. alpha feto protein(AFP)
Time frame: whinin 7 days before transplantation, 1,3,6 and 12 months after transplantation
liver enzyme fiber spectrum
1. laminin (LN) 2. Ⅳ collagen detection (CIV) 3. hyaluronic acid (HA) 4. procollagen Ⅲ(PC Ⅲ)
Time frame: whinin 7 days before transplantation, 1,3,6 and 12 months after transplantation
coagulation
1. prothrombin time (PT) 2. activated partial thromboplastin time (APTT) 3. fibrinogen (FIB) 4. thrombin time (TT)
Time frame: whinin 7 days before transplantation, 1,3,6 and 12 months after transplantation
portal vein and splenic vein measure
1. Portal vein diameter (Dpv); 2. Portal vein maximum velocity (Vmaxpv); 3. Portal vein blood flow per minute (Qpv); 4. The splenic vein diameter (Dsv); 5. Splenic vein maximum flow velocity (Vmaxsv); 6. Splenic vein blood flow per minute (Qsv).
Time frame: whinin 7 days before transplantation, 1,3,6 and 12 months after transplantation
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