Sinusitis in Children and the Nasopharyngeal Microbiome

University of Wisconsin, Madison323 enrolled

Overview

The purpose of this study is to investigate the relationship between viral infections of the upper respiratory tract, perturbations of the nasopharyngeal microbiome in children, and the risk of acute bacterial sinusitis over a one year period. The investigators will determine the incidence of acute bacterial sinusitis post viral upper respiratory infection and identify the viral antecedent infections and other risk factors which predispose to infection and ultimately design strategies to reduce the burden of disease and antimicrobial resistance.

Study Type

OBSERVATIONAL

Enrollment

323

Conditions

Sinusitis

Eligibility

Sex: ALLMin age: 4 YearsMax age: 7 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Children 4 to 7 years of age * Healthy * English-speaking parent/guardian - Exclusion Criteria: * Any underlying condition which would predispose them to the development of sinusitis including congenital or acquired immunodeficiencies * Craniofacial abnormalities * Cystic fibrosis * Allergic rhinitis or a previous episode of chronic sinusitis.

Locations (2)

UW Pediatrics at 20 S. Park St

Madison, Wisconsin, United States

UW Health West Towne Pediatrics

Madison, Wisconsin, United States

Outcomes

Primary Outcomes

Incidence of acute bacterial sinusitis in children 49 to 84 months of age (which is the peak age incidence of sinusitis) as a complication of an antecedent viral upper respiratory infection.

Time frame: Over a 1 year time frame

Secondary Outcomes

Define relationships between the nasopharyngeal microbiome, viral illnesses, and progression to clinical sinusitis.

Time frame: Over a 1 year time frame

Data from ClinicalTrials.gov

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