Chemotherapy Combined With Whole-body Hyperthermia to Treat Stage IIIB/IV Non Small Cell Lung Cancer

Inclusion Criteria: 1. Older than 18, survive more than 3 months; 2. Pathologically or cytologically proven stage IIIB/IV non small cell lung cancer(NSCLC); 3. Measurable disease, defined as lesions that can be accurately measured in at least one dimension (longest diameter to be recorded) as ≥ 2 cm with conventional techniques or as ≥ 1 cm with spiral CT scan No known CNS tumors, including brain metastases; 4. ECOG performance status 0-2; 5. Granulocytes ≥ 1,500/μL Platelets ≥ 75,000/μL Hemoglobin ≥ 8.5 g/dL Bilirubin ≤ 3 mg/dL ALT and AST ≤ 2 times upper limit of normal (ULN) PT/INR ≤ 1.7 (therapeutic anticoagulation \[e.g., coumadin or heparin\] allowed provided there is no prior evidence of underlying abnormality in these parameters) Creatinine ≤ 1.5 times ULN OR creatinine clearance ≥ 60 mL/min; 6. Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception before, during, and for 30 days after completion of study therapy; 7. Other prior adjuvant therapy is allowed provided it was completed \> 6 months ago AND there is documented recurrence of NSCLC; 8. No prior local therapy for the target lesion unless the target lesion located within the field of local therapy has shown ≥ 25% increase in size since last treatment; 9. At least 4 weeks since prior and no concurrent palliative radiotherapy No concurrent combination anti-retroviral therapy for HIV; 10. volunteers who signed informed consent. Exclusion Criteria: 1. During Screening period and treatment period, the main target for lesions has been given radiation; 2. The body has metal material, including a metal JieYuHuan/support/operation fixed material within; 3. Existing cerebrovascular diseases and central nervous system tumors, including metastatic carcinoma; 4. Patients with recent or ongoing gastrointestinal bleed may not be transfused to reach the entry hemoglobin of 8.5 g/dL Physicians should ensure patients requiring transfusion prior to registration do not have an occult or clinically apparent gastrointestinal bleed No history of bleeding diathesis; 5. No significant history of cardiac disease, including any of the following: NYHA class III-IV congestive heart failure Myocardial infarction within the past 6 months Cardiac arrhythmias requiring anti-arrhythmic therapy (other than beta blockers or digoxin) LVEF \< 45% (or below the normal limit at the individual institution) by scintigraphy (MUGA or myocardial scintigram) History of hypertension allowed provided it is well controlled (i.e., BP \< 140/90 mm Hg) on a regimen of anti-hypertensive therapy 6. Other prior adjuvant therapy is allowed provided it was completed \> 6 months ago AND there is documented recurrence of NSCLC 7. No prior systemic therapy for metastatic disease At least 4 weeks since prior locoregional therapy (e.g., embolization, chemoembolization \[except with doxorubicin hydrochloride\], radiotherapy, or radioactive microspheres) 8. No prior local therapy for the target lesion unless the target lesion located within the field of local therapy has shown ≥ 25% increase in size since last treatment 9. poor Compliance, not receiving medication or follow-up according to study plan; 10. There are other serious situations contrary to the scheme 11. Existing tuberculosis; 12. Exist two or multiple tumors