The aim of the study is to estimate the impact of the protein content of breastmilk at the end of hospitalization of the preterm newborn, on the neurodevelopment at 2 years old. The investigators expect a difference of at least 5 points of Development Quotient (DQ) when comparing extreme terciles of the protein content of breastmilk at the end of hospitalization.
Study Type
OBSERVATIONAL
Enrollment
160
Samples of breastmilk and infant serum and questionnaires.
University Hospital of Nantes
Nantes, France
To assess the impact of the protein content of human milk on the neuro-motor development of the preterm infant at 2 years of age
ASQ (Ages and Stages Questionnaires) score at 2 years of age. The calculation of the sample size is only based on this endpoint. We wish to highlight a difference of at least 25 points of the ASQ score between both extreme terciles of protein concentration determined in breast milk at the end of hospitalization, when breastfeeding is exclusive (last sample of breastmilk before the end of hospitalization).
Time frame: At 2 years of age
To assess the impact of the protein content of human milk on the Body composition (% fat/lean mass)
Body composition (% fat/lean mass)
Time frame: At 2 years of age and at 7-8 years of age
To assess the impact of the protein content of human milk on feeding behavior
Dietary behavior
Time frame: At 2 years of age and at 7-8 years of age
To assess the impact of the protein content of human milk on growth trajectory and metabolic status of the preterm infant
Staturo-weight growth rate
Time frame: At 2 years of age and at 7-8 years of age
To assess the impact of the protein content of human milk on the coginitive intelligence of the preterm infant
Standardized and validated test WISC V
Time frame: At 7-8 years of age
To assess the impact of the protein content of human milk on the executive functioning of the preterm infant
Standardized and validated test FEE
Time frame: At 7-8 years of age
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To assess the impact of the protein content of human milk on the executive dysfunction of the preterm infant
Standardized and validated test BRIEF battery
Time frame: At 7-8 years of age
To assess the impact of the protein content of human milk on the child's behaviour in the classroom of the preterm infant
Standardized and validated test GSA
Time frame: At 7-8 years of age
To assess the impact of the protein content of human milk on the generalist clinical evaluation of the preterm infant
Standardized and validated test BMT-i
Time frame: At 7-8 years of age
To assess the impact of the protein content of human milk on the physical activity of the preterm infant
Actimeter (ACTIGRAPH®)
Time frame: At 7-8 years of age
To assess the impact of the protein content of human milk on the physical activity of the preterm infant
ESTEBAN questionnaire (Santé Publique France).
Time frame: At 7-8 years of age