Discontinuation Order of Vasopressors in Septic Shock

Inclusion Criteria: * patients 20 years of age or older * patients of receiving concomitant therapy with norepinephrine and vasopressin for teh management of septic shock * patients began to reduce the vasopressor Exclusion Criteria: * patients who expired or had care withdrawn while receiving norepinephrine and vasopressin * patients being transferred into the ICU from an outside facility or the operating room * patients who are suspected to have vasopressin deficiency (eg. HPA axis dysfunction, empty sella) * acute myocardial infarction or Congestive heart failure (NYHA functional classification III or IV) * acute mesenteric ischemia * patients who were received other vasopressor except for norepinephrine or vasopressin