The Study of Minocycline for Negative and Cognitive Symptoms in Schizophrenia

Inclusion Criteria: * male and female,were aged 18-40 years * were currently diagnosed with DSM-IV schizophrenia * were able to comprehend the cognition test * patients or guardian signed informed consent,were able to comprehend the procedure and aims of the study,agreed to join the study * patient's current antipsychotic medication regimen must be stable * must be in a stable living arrangement Exclusion Criteria: * had ever been hypersensitivity to minocycline or tetracycline; * had acute,unstable,significant,or untreated medical illness besides schizophrenia * were pregnant or breast-feeding; * had a DSM-IV diagnosis of substance abuse or dependency; * had a tendency to suicide or Violence,self-harm; * had taken immunosuppressive agents in the preceding 3 months before study entry; * had influenza or fever in the preceding 2 weeks before study entry; * had a DSM-IV diagnosis of emotional psychosis,Mental retardation,etc. * has suicidal attempts or ideation or violent behavior within the last 12 months * patient has mental retardation or severe organic brain syndromes * treatment with Electroconvulsive Therapy (ECT) within 6 months prior to screening