Biomarkers in Samples From Younger Patients With Wilms Tumor

Children's Oncology Group30 enrolled

Overview

This research study is studying biomarkers in tissue samples from younger patients with Wilms tumor. Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors predict how patients respond to treatment

PRIMARY OBJECTIVES: I. To determine whether recruitment of tumor-associated macrophages is related to clinicopathological factors in Wilms tumor (tumor stage, presence of vascular invasion, tumor progression, and survival). OUTLINE: Paraffin-embedded specimens are analyzed for macrophage markers. Results of each sample are then compared with patient's tumor stage, presence of vascular invasion, tumor progression, and survival.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Wilms Tumor and Other Childhood Kidney Tumors

Interventions

laboratory biomarker analysisOTHER

Correlative studies

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Wilms tissue microarray samples provided by the Children's Oncology Group

Locations (1)

Children's Oncology Group

Monrovia, California, United States

Outcomes

Primary Outcomes

Relationship of tumor-associated macrophages and prognosis

Correlation of each type of macrophage score with tumor staging, presence of vascular invasion, and disease-free survival will be assessed.

Time frame: 1 month

Data from ClinicalTrials.gov

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