Nab-paclitaxel and carboplatin showed better treatment response compared with cremophor-based paclitaxel and carboplatin as first-line therapy in advanced non-small cell lung cancer, especially for squamous cell cancer. The regimen of weekly nab-paclitaxel, carboplatin and concurrent radiotherapy was well tolerated in a phase I study. Given nab-paclitaxel, carboplatin and concurrent radiotherapy in patients with local advanced squamous cell lung cancer may have promising result.
This study was conducted to explore the efficacy and toxicity of concurrent chemoradiotherapy with nab-paclitaxel, carboplatin and thoracic radiotherapy in unresectable local advanced squamous cell lung cancer. Patients will be given nab-paclitaxel weekly at a dose of 60mg/m2, in combination with carboplatin (AUC 2) weekly during concurrent chemoradiotherapy. Thoracic radiation was administered at a dose of 66 Gy/33 fractions, both 3 dimensional conformal and intensity modulated radiation therapy are allowed. Two cycles of consolidation therapy with full dose nab-paclitaxel (260 mg/m2 on day 1) and carboplatin (AUC 6 on day 1) every 21 day will be delivered.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
21
concurrent: 60 mg/m2, IV, weekly; consolidation: 260 mg/m2, IV, every 3 weeks
concurrent: AUC 2, IV, weekly; consolidation: AUC 6, IV, every 3 weeks
66 Gy in 33 fractions,both three-dimensional conformal and intensity modulated radiation therapy are allowed
Hangzhou Cancer Hospital
Hangzhou, Zhejiang, China
RECRUITINGThe First People's Hospital of Hangzhou
Hangzhou, Zhejiang, China
ACTIVE_NOT_RECRUITINGtumor response rate
Time frame: one month after the end of all treatment
progression-free survival
Time frame: 2 years from patient enrollment
overall survival
Time frame: 2 years from patient enrollment
esophagitis
acute esophagitis of Grade III and above
Time frame: 6 mouths from the initiation of treatment
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