A Study on the Effects of Valproate on the Pharmacokinetics of RO4917838 in Healthy Volunteers

Inclusion Criteria: * Healthy male volunteers, 18 to 65 years of age inclusive * Body mass index (BMI) 18 to 30 kg/m2 inclusive * Healthy as determined by the investigator on the basis of medical/surgical history, physical examination, clinical laboratory test results, vital signs, and a 12-lead electrocardiogram (ECG) * Non smoker or smoker of fewer than 10 cigarettes per day Exclusion Criteria: * History of alcoholism, drug abuse or addiction within the last year prior to Day -1 of the study * Alcohol consumption averaging more than 24 g of alcohol per day * History of any significant cardiovascular, hepatic, renal, respiratory, gastrointestinal, endocrine, immunologic, allergic, dermatologic, hematologic, neurologic, psychiatric disease, or cancer * Any major illness within the 4 weeks prior to dosing or any acute disease state (e.g. nausea, vomiting, fever, diarrhea) within 7 days of study Day -1 * Any confirmed allergic reactions against any drug, or multiple allergies in the judgment of the investigator * Positive for hepatitis B, hepatitis C or HIV infection * Involvement in other investigational studies of any type within 90 days of first study drug administration or within 5 times the elimination half-life of the tested drug, whichever is longer