Surgical Stress Measured by Microdialysis

Northern Orthopaedic Division, Denmark16 enrolled

Overview

Paraspinal muscle damage is inevitable during conventional posterior lumbar fusion surgery. Minimal invasive surgery is postulated to result in less muscle damage and better outcome. The aim of this study is to monitor metabolic changes of the paraspinal muscle and to evaluate paraspinal muscle damage during surgery using microdialysis (MD).

Posterior approach is a common and important surgical procedure for various lumbar diseases. Owing to the anatomy, the damage of paraspinal muscle is inevitable during conventional posterior lumbar fusion surgery. Degeneration and malfunction of the paraspinal muscle might associate with pain and inferior postoperative clinical outcome.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Trauma

Interventions

Posterolateral lumbar fusion surgeryPROCEDURE

Two MD catheters with 1% lidocaine 1-2 ml are placed in the paraspinal muscle.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria: * patients who undergo conventional instrumented posterolateral lumbar fusion. Exclusion criteria: * previous fusion * chronic metabolic disease * tumor or metastasis * postoperative surgical complications and complications during surgery

Outcomes

Primary Outcomes

The glycerol concentration

To study whether the glucerol concentration can be used to evaluate surgery related paraspinal muscle damage

Time frame: Two hours

Data from ClinicalTrials.gov

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