Endophthalmitis Cultures

Vanderbilt University3 enrolled

Overview

The intent of this surveillance study will be to obtain written permission from patients with bacterial endophthalmitis in order to compare sterilization rates of their cultured bacterial isolates to standard therapy (vancomycin and ceftazidime) versus combination therapy with vancomycin, ceftazidime, and moxifloxacin. Research hypothesis: 1. Cultured bacterial isolates will demonstrate faster in vitro sterilization rates with combination treatment (vancomycin, ceftazidime, and moxifloxacin) compared to "standard therapy" with vancomycin and ceftazidime. 2. Longitudinal analysis of resistance patterns of cultured isolates will show increasing rates of multi-antibiotic resistance.

Adult patients over 18 years of age presenting with endophthalmitis and able to sign consent.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Endophthalmitis

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * all adult patients age 18 or greater presenting with bacterial endophthalmitis to the Vanderbilt Eye Institute and who grow positive cultures Exclusion Criteria: * Patients \< 18 years of age or those patients without positive cultures

Locations (1)

Vanderbilt Eye Institute

Nashville, Tennessee, United States

Data from ClinicalTrials.gov

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