The purpose of this study is to determine whether active repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex is safe and effective for preventive treatment of chronic migraine, compared to placebo repetitive transcranial magnetic stimulation.
Patients with chronic migraine according to the criteria of the International Headache Society will be randomized to either active repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex or placebo repetitive transcranial magnetic stimulation, in a total of 23 sessions of treatment (15 sessions in the first month and 8 sessions in the second month of treatment). Outcomes will be evaluated at baseline, after one, two months after treatment, and one month after end of treatment
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
18
10Hz active rTMS delivered to the left dorsolateral prefrontal cortex
10Hz placebo rTMS delivered to the vertex
Instituto Israelita de Ensino e Pesquisa Albert Einstein
São Paulo, Brazil
number of days with pain per month
Time frame: After all treatment sessions (total, 23 sessions within 60 days)
adverse effects
Time frame: After all treatment sessions (total, 23 sessions within 60 days)
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