AMG 172 First in Human Study in Patients With Kidney Cancer

Inclusion Criteria: * Subjects must have a pathologically documented, definitively diagnosed, clear cell RCC that is relapsed/refractory following at least two lines of systemic therapy (one of which must be a tyrosine kinase), or the subject refuses standard therapy * Measurable disease per RECIST 1.1 criteria. Subjects with non-measurable, but evaluable disease are also eligible for Part 1 of the study. * Eastern Cooperative Oncology Group (ECOG) Performance Status of ≤ 1 * Willing to provide tumor samples and / or slides * Hematological function, as follows: 1. Absolute neutrophil count (ANC) ≥ 1.5 x 10\^9/L; 2. Platelet count ≥ 100 x 10\^9/L; 3. Hemoglobin \> 9 g/dL * Prothrombin time (PT) or partial thromboplastin time (PTT) \< 1.5 x institutional upper limit of normal (IULN) * Hepatic function, as follows: 1. Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) \< 3 x ULN; 2. Total bilirubin \< 1.5 x ULN (\< 3.0 x ULN for subjects with documented Gilbert's Disease or for whom the indirect bilirubin level suggests an extrahepatic source of elevation); 3. Alkaline phosphatase \< 2 x ULN (\< 5 x ULN in subjects whom the PI and sponsor agree that clinical data suggest extrahepatic source of elevation) * Other inclusion criteria may apply Exclusion Criteria: * Known primary central nervous system (CNS) tumors or brain metastases * History of bleeding diathesis * Myocardial infarction within 6 months of study day 1, symptomatic congestive heart failure (New York Heart Association \> class II), unstable angina, or unstable cardiac arrhythmia requiring medication, or uncontrolled hypertension in the opinion of the investigator * Clinically significant ECG changes which obscure the ability to assess the PR, QT, and QRS interval; congenital long QT syndrome * A baseline ECG QTcF \> 470 msec * Known positive test for human immunodeficiency virus (HIV) * Known acute or chronic hepatitis B or hepatitis C infection as determined by serologic tests * Other exclusion criteria may apply