Post-Infectious Irritable Bowel Syndrome (PI-IBS)

KU Leuven131 enrolled

Overview

Purpose: * identification of factors predisposing for Post-Infectious Irritable Bowel Syndrome (PI-IBS) development after an episode of traveler's diarrhea * identification of systemic (serum) and local (biopsy) changes in infectious and immunological activity during infection and correlation with Irritable Bowel Syndrome (IBS) symptoms, persisting after traveler's diarrhea Design: * 4 study visits: before traveling, 2 weeks after traveling, 6 months after traveling, 12 months after traveling * at each study visit following investigations: blood collection, stool collection, questionnaires, rectal biopsy

Study Type

OBSERVATIONAL

Enrollment

131

Conditions

Irritable Bowel Syndrome With Diarrhea

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * traveling to South-America, Africa, South-East Asia * 18-70 years * traveling for 1-10 weeks Exclusion Criteria: * Chronic diarrhea * Pregnant * Colitis Ulcerosa * Morbus Chrohn * IBS * Coeliakie * Gastrointestinal malabsorption * microscopic colitis * diverticulitis * immune deficiency * use of antibiotics/corticosteroids 2 weeks before travelling

Locations (1)

University hospitals Leuven

Leuven, Vlaams-Brabant, Belgium

Outcomes

Primary Outcomes

postinfectious IBS symptoms (ROME III criteria) 1 year after travelers diarrhea episode

Time frame: 1 year after traveling

Data from ClinicalTrials.gov

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