Role of Biomarkers in Disease Progression in Samples From Patients With Acute Myeloid Leukemia

Children's Oncology Group20 enrolled

Overview

RATIONALE: Studying samples of blood, tissue, and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies the role of biomarkers in disease progression in samples from patients with acute myeloid leukemia.

OBJECTIVES: * To determine the subcellular localization of the MLL-AF1q fusion protein in leukemia cells. OUTLINE: Cryopreserved specimens are analyzed for MLL-AF1q fusion protein and AF1 gene expression by mass spectrometry, western blot analysis, semi-quantitative PCR, and qPCR.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Leukemia

Interventions

gene expression analysisGENETIC

gene rearrangement analysisGENETIC

polymerase chain reactionGENETIC

protein analysisGENETIC

Eligibility

Sex: ALLMax age: 30 Years

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Cryopreserved acute myeloid leukemia specimens PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Outcomes

Primary Outcomes

Subcellular localization of the MLL-AF1q fusion protein in leukemia cells

Data from ClinicalTrials.gov

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