The Impact of Continuous Renal Replacement Therapy on the Outcomes of Burn Patients With Early Phase of Sepsis

Inclusion Criteria: * patients with documented sepsis * clinically identified focus of infection associated with at least 2 SIRS -criteria and one or more sepsis-induced organ failures within the 24 hours -prior to inclusion * age 18 to 70 years * severe burned patients with 50% \< TBSA \< 85% Exclusion Criteria: * cirrhosis child class C * too high APACHE II \& SOFA score at admission * age over 70 years * were presence of a malignant tumor, chronic renal insufficiency (serum creatinine \> 133 µmol/L), moribund state, receiving immunosuppressive therapy or receiving any kind of renal replacement therapy before randomization