Treatment of Natural Killer/T Cell Lymphoma-Ⅲ/Ⅳ

Inclusion Criteria: * Age range 14-70 years old; ECOG performance status 0-2; Estimated survival time \> 3 months * Histological confirmed NK/T cell lymphoma * None of chemotherapy or radiotherapy has been previously used * None of chemotherapy contraindication: hemoglobin ≥ 90 g/dl, neutrophil ≥ 1.5×109/L, platelet ≥ 100×109/L, ALT and AST ≤ 2×ULN, serum bilirubin ≤ 1.5×ULN, serum creatine ≤ 1.5×upper limitation of normal (ULN), Serum Albumin ≥ 30g/L, serum plasminogen is normal (Inclusion Criteria of 1,3,6 groups ) * At least one measurable lesion * None of other serious diseases, cardiopulmonary function is normal * Pregnancy test of women at reproductive age must be negative * Patients could be followed up * None of other relative treatments including the traditional Chinese medicine, immunotherapy,biotherapy except anti-bone metastasis therapy and other symptomatic treatments. * volunteers who signed informed consent. Exclusion Criteria: * Disagreement on blood sample collection * Patients allergic of any of drug in this regimen or with metabolic disorder * Pregnant or lactating women * Serious medical illness likely to interfere with participation * Serious infection * Primitive or secondary tumors of central nervous system * Chemotherapy or radiotherapy contraindication * The evidence of CNS metastasis * History of peripheral nervous disorder or dysphrenia * patients participating in other clinical trials * patients taking other antitumor drugs * patients estimated to be unsuitable by investigator