Pharmacokinetics of Somatropin in Patients With End Stage Renal Disease Receiving Chronic Haemodialysis

Inclusion Criteria: * PATIENTS: * Male or female, age equal to or above 18 years undergoing chronic haemodialysis * Stable and adequate haemodialysis treatment three months prior to enrolment * HEALTHY SUBJECTS: * Matching an individual of the patient group by: Gender and age (± 5 years) * Matching an individual of the patient group by weight (after dialysis, ±10%) * Creatinine clearance above 80 ml/min * Subjects must be in good health in accordance with their age as determined by a medical * history, physical examination, vital signs, ECG (electrocardiogram), routine haematology and clinical chemistry Exclusion Criteria: * Use of cuprophane membranes * Active malignant disease * Diabetes * Critical illness as defined by the need of respiratory or circulatory support * Known or suspected allergy to the trial product * Pregnancy, breast feeding, the intention of becoming pregnant or fertile women judged to be * using inadequate contraceptive measures * Blood Pressure (pre-dialysis) above 180/110 * Chronic treatment with steroids in doses above 10 mg/day prednisolone (or equivalent) * Treated with immunosuppressive agents