This investigation will address the safety and feasibility of distal, intra-arterial sampling through endovascular access, in acute stroke patients. Levels of Magnesium will be measured in the region of infarct in patients who had been treated with intravenous Magnesium therapy following an acute stroke. This study attempts to address whether the traditional intravenous means of neuroprotectant administration achieves adequate concentration of the therapeutic agent in the area of diseased tissue.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
2
Paired sampling from the distal arterial(endovascular catheter) and peripheral venous (femoral sheath) locations: withdrawal of 3ml of blood from vasculature distal to the occlusive thrombus
University California Los Angeles: Ronald Reagan and Santa Monica Hospitals
Los Angeles, California, United States
University of Southern California University and LA County Hospitals
Los Angeles, California, United States
Magnesium concentration
The primary endpoint is the relative concentration of Mg in the core cerebral ischemic zone, compared to systemic therapeutic Mg levels, as a measure of delivery efficacy of systemic administration.
Time frame: intra-procedure (at time of first pass of retrieval device)
Sampling feasibility
sampling feasibility will be determined by the proportion of cases in which a cerebral circulation Mg level was successfully assayed
Time frame: intra-procedural (at time of first pass of retrieval device)
Safety
safety will be assessed by intraoperative adverse events, postoperative neurologic examination including NIH stroke scale, and postoperative brain imaging.
Time frame: post-operative day 1
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