High Resolution Optical Imaging of Barrett's Esophagus Using Nvision Volumetric Laser Endomicroscopy (VLE)

Inclusion Criteria: * Males and females over the age of 18 years. * Patients with either suspected BE presenting for endoscopy or patients with documented BE presenting for follow-up endoscopy likely to require a biopsy or patients presenting for endoscopy for non-BE related conditions other than esophageal varices. * Ability to provide written, informed consent. * Females who are able to become pregnant, are willing to take a pregnancy test. Exclusion Criteria: * Patients on anticoagulation undergoing high risk procedures in accordance to American Society For Gastrointestinal Endoscopy (ASGE) guideline for the management of antithrombotic agents for endoscopic procedures (2009). * Patients with esophageal varices that preclude biopsies. * Presence of an esophageal mass that precludes full distention of the balloon from the Nvision balloon guide sheath. * Patients with esophageal strictures that would prevent adequate expansion of the balloon from the Nvision balloon guide sheath. * Patients with known inflammatory disease, esophageal tears or ulcers, which would prohibit full distention of the balloon from the Nvision balloon guide sheath. * Patients with known eosinophilic esophagitis. * Patients that are pregnant. * Patients with a history of hemostasis disorders.