Overactive bladder syndrome (OAB) affects around 17 % of female population. However, the etiology of OAB was complicated and unclear in many aspects. In particular, the research about psychiatric aspect of etiology in OAB was paucity. Besides, research about prognostic factors and impact of cardiovascular system of OAB treatment was also paucity. Therefore the aims of the investigators study were (1) to analyze the etiology of OAB in psychiatric aspects; (2) to analyze the prognostic factors associated with tolterodine treatment; (3) to analyze the differences of cardiac conduction and heart rate variability before and after tolterodine treatment; (4) to analyze the differences of arterial stiffness between non-OAB and OAB female patients, and before and after tolterodine treatment.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
155
The enrolled women before March 2009 were treated with tolterodine 4 mg slow-release, and after March 2009 were treated with solifenacin 5 mg once a day for 12 weeks.
Department of Gynecology,National Taiwan University Hospital
Taipei, Taiwan
Changes of heart rate variability after antimuscarinics
Changes of heart rate variability after 3-months' antimuscarinics treatment
Time frame: 3 months
Changes of arterial stiffness after antimuscarinics treatment
Changes of arterial stiffness after 3-months antimuscarinics' treatment
Time frame: 3 months
Changes of psychologic distress after antimuscarinics treatment
Changes of psychologic distress after 3-months' antimuscarinics treatment
Time frame: 3 months
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