The purpose of this study is to compare the neonatal outcome and infant neurologic outcome whose mother were treated with cefazolin plus clarithromycin for one week or until delivery after preterm premature rupture of membrane.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
151
Cefazolin 1.0gm IVs q 12 hours after randomization for one week
clarithromycin 500mg po bid after randomization for one week
Cefazolin 1.0gm IVs q 12 hours after randomization until delivery
Samsung Medical center, Sungkyunkwan University School of Medicine
Seoul, South Korea
Neonatal composite morbidity
1. respiratory distress syndrome(RDS) 2. bronchopulmonary dysplasia(BPD) 3. intraventricular hemorrhage(IVH,≥grade 3) 4. retinopathy of prematurity(ROP,≥grade 3) 5. necrotizing enterocolitis(NEC,≥stage 2) 6. proven neonatal sepsis
Time frame: Participants will be followed for duration of hospital day after delivery, an expected average of 8 weeks
infantile neurologic outcome
The outcome will be evaluated in five sub-domains (development, neurologic examination, Bayley Scales of Infant Development-II, vision, and hearing). The final outcome scale was divided into normal, mild, moderate, and severe disability
Time frame: at 6 months and 1 year of corrected age
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clarithromycin 500mg po bid after randomization until delivery