Phase 1/2 Lyme Vaccine Study

Main Inclusion Criteria: * Subject is 18 to 70 years old at the time of screening * Subject has an understanding of the study, agrees to its provisions, and gives written informed consent prior to study entry * Subject is generally healthy, as determined by the investigator's clinical judgment through collection of medical history and the performance of a physical examination * If female of childbearing potential, presents with a negative urine pregnancy test, and agrees to employ adequate birth control measures for the duration of the study Additional inclusion criterion for seropositive subjects in Section 2 only: \- Subject is seropositive for Borrelia burgdorferi sensu lato (s.l.) antibodies at study entry Main Exclusion Criteria: * Subject has a physician-diagnosed chronic illness related to Lyme borreliosis (LB) or active LB * Subject has been treated for LB with antibiotics within 3 months of study entry * Subject had a tick bite within 3 weeks prior to screening or first vaccination * Subject has a history or active infection with Babesia microti (babesiosis) or Anaplasma phagocytophilum (ehrlichiosis) * Subject currently has or has a history of significant cardiovascular, respiratory (including asthma), metabolic, neurological, hepatic, rheumatic, autoimmune, hematological, gastrointestinal or renal disorder * Subject has clinically significant abnormal laboratory values at screening * Subject currently has or has a history of immunodeficiency * Subject tests positive for human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg) or hepatitis C virus (HCV) * Subject has a disease or is currently undergoing a form of treatment or was undergoing a form of treatment within 30 days prior to study entry that could be expected to influence immune response. * Subject has a history of anaphylaxis or severe allergic reactions * Subject has received any live vaccine within 4 weeks or inactivated vaccine within 2 weeks prior to vaccination in this study * Subject is pregnant or lactating at the time of study enrollment Additional exclusion criterion for subjects in Section 1 and seronegative subjects in Section 2: \- Subject is seropositive for Borrelia burgdorferi sensu lato (s.l.) antibodies at study entry