This is a prospective, multi-center observational study designed to address patient-reported nasal outcomes in adults undergoing endoscopic and microscopic surgical removal of pituitary tumors. The primary objective of this study is to determine the difference in nasal outcomes by using the Anterior Skull Base (ASK) Nasal survey between patients treated with endoscopic surgical technique and those treated with microscopic surgical technique. Patients will be given the ASK Nasal survey to assess their nasal functioning and overall health before their surgery, and at post-operative visits 1-2 weeks, 3 months, and 6 months.
The technical and patient factors that influence rhinological (nasal) outcomes following endonasal anterior skull base surgery and pituitary surgery are not well understood. Several timely and controversial topics, such as the influence of endoscopic techniques and the impact of underlying disease on nasal outcomes are in need of further study. The Anterior Skull Base (ASK) Nasal survey is a 24-item questionnaire designed to assess for common postoperative nasal complaints, such as crusting, nasal congestion, pain, sinusitis, sense of smell, and overall functioning. The survey is a brief and simple assessment that asks patients to score symptom severity on a five-point scale.
Study Type
OBSERVATIONAL
Enrollment
235
Barrow Neurological Institute/St. Joseph's Hospital and Medical Center
Phoenix, Arizona, United States
John Wayne Cancer Institute at St. John's Health Center
Santa Monica, California, United States
Northshore University Health System
Chicago, Illinois, United States
Ohio State University Medical Center
Columbus, Ohio, United States
ASK Nasal symptom severity scores and SF-8 scores
Compare symptom severity scores and quality of life scores in first-time surgery patients with nonfunctioning adenomas on the ASK Nasal and SF-8.
Time frame: 3 months
Validation of ASK Nasal survey tool
Validate a nasal outcomes scale (ASK Nasal) specifically designed for anterior skull base surgery.
Time frame: 3 months
ASK Nasal symptom severity scores
* Evaluate the symptom severity scores on the ASK Nasal for first time surgery patients with nonfuctioning adenomas at the first post-operative visit and at 6 months. * Evaluate the symptom severity scores on the ASK Nasal for all patients at the first post-operative visit and at 6 months.
Time frame: 2 weeks, 3 months, 6 months postoperative
Impact of surgical techniques and complications on ASK Nasal scores
* Subgroup analysis on the impact of such surgical techniques, such as middle turbinate resection and nasal packing, on ASK Nasal scores will be performed. * Subgroup analysis of rhinological complications, such as sinusitis, on ASK Nasal scores. * Objective intranasal endoscopy findings at follow-up visits.
Time frame: 6 months
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