Corneal Endothelial Changes Following Pediatric Cataract Surgery With IOL Implantation

Iladevi Cataract and IOL Research Center106 enrolled

Overview

Cataract surgery is known to cause loss of corneal endothelial cells. In adults, it is reported that anywhere between 2 to 15% loss of corneal endothelial cell density occurs following cataract surgery. However, no data is available regarding endothelial changes after cataract surgery with IOL implantation in pediatric eyes. The aim of this study is to prospectively observe changes in endothelial cell density, coefficient of variation and hexagonality following cataract surgery with IOL implantation in pediatric eyes.

Study Type

OBSERVATIONAL

Enrollment

106

Conditions

Congenital Cataract Surgery IOL Implantation Change in Corneal Endothelial Cell Morphology

Interventions

Congenital Cataract Surgery

Eligibility

Sex: ALLMin age: 4 YearsMax age: 15 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Eyes undergoing pediatric cataract surgery with IOL implantation at Iladevi Cataract \& IOL Research Center, Ahmedabad, India. * Children older than 4 years undergoing cataract surgery with IOL implantation were included. Exclusion Criteria: * Exclusion criteria were as follows: eyes with traumatic or subluxated cataract and inability to get preoperative specular. Intraoperatively, sulcus fixated IOLs, and eyes with no IOL implantation were excluded.

Outcomes

Primary Outcomes

Corneal endothelial morphology

Change in corneal endothelial cell density, (CD), coefficient of variation (CV) and % of hexagonality (6A) were studied from preoperatively to 3 months postoperatively

Time frame: preoperatively to 3 months postoperatively

Secondary Outcomes

Change in central corneal thickness

Change in central corneal thickness from preop to 3 months postop was studied

Time frame: preoperatively to 3 months postoperatively