Adaptive Radiation Treatment for Head and Neck Cancer

Inclusion Criteria: * biopsy-confirmed squamous cell carcinoma of the oropharynx, oral cavity or hypopharynx * stage III/IV, T3-4, Nx M0 * \< 70 yrs * glomerular filtration rate (GFR) \>60 * WHO 0-1 * no previous malignancies except for adequately treated basal cell carcinoma of the skin and carcinoma in situ of the cervix * adequate bone marrow function, adequate hepatic function,informed consent * \>18 years Exclusion Criteria: * expected failure from follow-up * previous malignancies except for adequately treated basal cell carcinoma of the skin and carcinoma in situ of the cervix * expected inability to complete either one of the treatment arms * pregnancy or lactation * patients (m/f) with reproductive potential not implementing adequate contraceptive measures * prior surgery, radiotherapy or chemotherapy for this tumor * contraindications or serious concomitant diseases preventing the safe administration of chemotherapy and/or radiotherapy or are likely to interfere with the study assessments * known active symptomatic fungal, bacterial and/or viral infections including HIV * concomitant (or with 4 weeks before randomisation) administration of any other experimental drug * concurrent treatment with any other anti-cancer therapy * prior treatment with one or more of the active compounds