RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This research study is studying biomarkers in samples from patients with acute lymphoblastic leukemia enrolled on ECOG-2993 clinical trial.
OBJECTIVES: * To identify microRNAs that behave as oncogenes or as tumor suppressor genes in B-lineage acute lymphoblastic leukemia (ALL) in vitro and in vivo. * To examine if single microRNA or signatures of microRNA correspond to different clinical outcomes in cytogenetically distinct B-ALL groups. OUTLINE: RNA from archived samples are analyzed for microRNA expression profile in vitro and in vivo.
Study Type
OBSERVATIONAL
Enrollment
186
Comprehensive view of microRNA expression by cytogenetic subgroup
Time frame: 1 year
MicroRNA expression in relation to clinical outcome
Time frame: 1 year
Differential microRNA expression between normal B-cells and progenitors compared to B-ALL
Time frame: 1 year
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