Effect of Timolol on Refractive Outcomes in Eyes With Myopic Regression After LASIK: a Randomized Clinical Trial

Shahid Beheshti University of Medical Sciences45 enrolled

Overview

In this randomized controlled clinical trial, we compare the effects of timolol versus placebo for treatment of myopic regression after LASIK

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Myopic Regression

Interventions

TimololDRUG

PlaceboDRUG

artificial tear twice a day

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with myopic regression equal or more than 0.5 D with minimum age of 20 years, * cylinder ≤ -1.00 D, * corrected distance visual acuity (CDVA) of at least 20/40 were included. Exclusion Criteria: * Patients with a history of previous ocular surgery, * keratoconus or any ectatic corneal disorder, * keratoconus suspect by topography, * preoperative corneal opacity, * any corneal dystrophies, * presence of pterygium, * retinal disorders, * collagen vascular disorders, * diabetes mellitus, * glaucoma, * cataract, * pregnancy, * breast feeding * systemic corticosteroid therapy were excluded.

Locations (1)

Ophthalmic Research Center

Tehran, Tehran Province, Iran

Outcomes

Primary Outcomes

Spherical Equivalent

Effect of timolol use in timolol group will be compared with placebo group at month 6. Moreover, the changes of intragroup spherical equivalent will be assessed in both group 6 months after timolol application.

Time frame: spherical equivalent at month 6

Data from ClinicalTrials.gov

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