Assessment of Zinc Absorption From a Phytic Acid Rich Complementary Food

Swiss Federal Institute of Technology40 enrolled

Overview

Assessment of zinc absorption from a phytic acid rich complementary food, consumed by young children immediately after the addition of the enzyme phytase. A randomized single blind study

Study Type

OBSERVATIONAL

Enrollment

Conditions

Bioavailability

Eligibility

Sex: ALLMin age: 12 MonthsMax age: 24 MonthsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. 12-24 month old 2. Male of female 3. Height and weight between -2.0 SD and +2.0 SD with respect to WHO child growth standards. 4. No mineral and vitamin supplements 2 weeks prior to the study and during the whole duration of the study Exclusion Criteria: 1. Body temperature ≥ 37.5°C 2. Hemoglobin ≤ 7g/dL 3. Positive RDT test 4. Any metabolic, gastrointestinal or chronic disease (according to the statement of the subject's parent) known chronic diseases at the gastrointestinal tract) 5. Long term mediation (that may affect zinc metabolism) during the whole study to interact with zinc metabolism (such as kidney diseases or

Locations (1)

CHU-Yalgado Ouédraogo, Service Pédiatrie

Ouagadougou, Burkina Faso

Outcomes

Primary Outcomes

Fractional absorption of zinc

Fractional absorption of zinc is estimated by using the double isotope tracer ratio technique by administering 67Zn as oral and 70Zn as intravenous stable isotopes.The urinary enrichment with both isotopes is measured in a spot urine sample by inductively coupled plasma mass spectrometry.

Time frame: 33 days

Data from ClinicalTrials.gov

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