Comparitive Study of Two Misoprostol Regimen in Early Pregnancy Termination

Hormozgan University of Medical Sciences41 enrolled

Overview

The aim of this study is to compare two misoprostol regimen in pregnancy termination.

Studies on determining the optimal dosage for misoprostol in pregnancy termination are continuing and still there is no evidence for ideal misoprostol regimen for pregnancy termination. The aim of this study is to compare two misoprostol regimen in pregnancy termination.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Termination

Interventions

Misoprostol 400 microgramsDRUG

Misoprostol 400 micrograms each 6 hours for 8 dose

Misoprostol 800 microgramsDRUG

Misoprostol 800 micrograms each 12 hours for 4 doses

Eligibility

Sex: FEMALE

Medical Language ↔ Plain English

Inclusion Criteria: * All women who were candidates for early pregnancy termination because of fetal death or other medical conditions * Before 14th week of gestation calculated according LMP or first trimester sonography Exclusion Criteria: * Chorioamnionitis * Hypersensitivity to prosstaglandins * Past medical history of cardiovascular, kidney or liver or lung diseases * Positive history for uterus pathologies * suspicious to extra-uterus pregnancy * sign and symptoms of uterus infection * Molar pregnancy

Locations (1)

Hormozgan University of Medical Sciences

Bandar Abbas, Hormozgan, Iran

Outcomes

Primary Outcomes

Abortion

After 48 hours after treatment each patient is assessed for abortion. Patients are devided into three groups including complete, partial or no abortion.

Time frame: 48 hours after treatment

Secondary Outcomes

Duration of abortion

Duration of abortion Form the begining of treatment to complete abortion

Time frame: Form the begining of treatment to complete abortion

Adverse Effects

including nausea, vomiting, fever and chill, diarhea, abdominal cramp, skin rash

Time frame: 48 hours after treatment

Need for surgery

Dilatation \& cartage

Time frame: 48 hours after treatment

Data from ClinicalTrials.gov

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