This trial is conducted in Europe. The aim of this trial is to determine the effect of NNC 90-1170 (liraglutide) on glucose and hormonal profiles, fasting gluconeogenesis and insulin secretion in subjects with type 2 diabetes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
17
6 mcg/kg injected subcutaneously daily in each treatment period in random order. In total, subjects are treated 9-10 days
6 mcg/kg injected subcutaneously daily in each treatment period in random order. In total, subjects are treated 9-10 days
Novo Nordisk Investigational Site
Århus C, Denmark
24-hour glucose profiles after three fixed meals
24-hour insulin profiles after three fixed meals
First phase insulin and maximal insulin secretory capacity
EGR (endogenous glucose release) expressed in mg/kg/min
GNG (gluconeogenesis) expressed in mg/kg/min
24-hour glucagon profiles after three fixed meals
24-hour FFA (free fatty acids) profiles after three fixed meals
4-hour paracetamol profiles after two fixed meals
30-hour NNC 90-1170 profile
Adverse events
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