Population Pharmacokinetics and Metabolomics of Theophylline in Preterm Infants

Seoul National University Hospital110 enrolled

Overview

1. Population pharmacokinetics : The purpose of this study is \- to investigate the population pharmacokinetics of theophylline in premature Korean infants and to assess the influence of demographic and clinical covariates. 2. Metabolomics : The purpose of this study are * to predict serum theophylline levels and to assess CYP1A2 activities in premature infants by analyzing urinary metabolites of theophylline * to examine which factors affect clearance of theophylline and CYP1A2 activity in premature infants

Study Type

OBSERVATIONAL

Enrollment

110

Conditions

Apea of Prematurity

Eligibility

Sex: ALLMax age: 37 Weeks

Medical Language ↔ Plain English

Inclusion Criteria: * Inborn preterm infants (GA \< 37 weeks) * Dx : Apnea of prematurity * Tx : Aminophylline / Theophylline * Informed consent of parents Exclusion Criteria: * Major congenital anomaly * Expired within 72 hours * Proven secondary apnea

Data from ClinicalTrials.gov

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