The purpose of this study is to determine the impact of phenylephrine versus ephedrine on organ perfusion, in women undergoing caesarean section receiving spinal anaesthesia. The organ perfusion is estimated by measuring the maternal cerebral oxygenation by NIRS(Near-infrared spectroscopy)and the foetal heartrate.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
24
An infusion with a maximum of 3 mg/minute for maximum 60 minutes or if sideeffects develope.
An infusion of maximum 4 mg/hour for maximum 60 minutes.
Naestved Hospital
Næstved, Denmark
Frontal lobe cerebral oxygenation
Determine the frontal lobe cerebral oxygantion by Near-Infrared Spectroscopy (NIRS),from before induction of spinal anaesthesia to end of surgery.
Time frame: Participants will be followed for the time in the operation theatre of the hospital stay, an expected average of 1 hour
Foetal heartrate
From before induction of spinal anaesthesia to 15 min after delivery
Time frame: Participants will be followed for the time in the operation theatre of the hospital stay, an expected average of 1 hour
Mean arterial pressure
The mean arterial pressure is measures from before induction of spinal anaesthesia to end of surgery.
Time frame: Participants will be followed for the time in the operation theatre of the hospital stay, an expected average of 1 hour
Cardiac output
The cardiac output is measures from before induction of spinal anaesthesia to end of surgery.
Time frame: Participants will be followed for the time in the operation theatre of the hospital stay, an expected average of 1 hour
Umbilical cord pH and Base excess
The umbilical cord blood analysis for evaluation of the newborn's acid-base status is taken immediately after delivery. It is the most objective way of assessing the fetal metabolic condition at birth.
Time frame: Blood analysis taken immediately after the the clamping of the umbilical cord, an average of 20 minutes.
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