A Clinical Trial of Anti-Angiogenic Drug Combination Tl-118 for Pancreatic Cancer Patients Who Are Starting Gemcitabine Treatment

Inclusion Criteria: 1. Age at least 18 years at enrollment. 2. Metastatic Pancreatic Cancer 3. The patient has histologically or cytologically confirmed pancreatic adenocarcinoma. 4. Patient has measurable disease by (RECIST). 5. Patient is starting standard of care Gemcitabine treatment 6. ECOG performance status ≤ 1 7. Adequate renal function 8. Adequate hepatic function 9. Adequate bone marrow reserve 10. Resolution of prior therapy acute adverse events. 11. Patient is capable of swallowing. 12. Patient's Informed Consent. - Exclusion Criteria: 1. Hypersensitivity to one or more of the TL-118 active components 2. Known Glucose-6-phosphate-dehydrogenase deficiency (G6PD). 3. CNS or Brain metastases 4. Prior systemic therapy for pancreas cancer 5. Subjects who received any investigational medication, prior local therapy for pancreas cancer , or any significant change in treatment within 1 month prior to screening 6. Concurrent use of any other investigational product 7. Subjects with a clinically significant or unstable medical condition that would preclude safe and complete study participation 8. Use of supplements or complementary medicines/botanicals, except for conventional multivitamin supplements, calcium, selenium and soy supplements. 9. Patient has known historical or active infection with HIV, hepatitis B, or hepatitis C 10. Circumstances likely to interfere with absorption of orally administrated drugs. 11. History of noncompliance to medical regimens or coexisting -